PPP2CA

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Protein phosphatase 2, catalytic subunit, alpha isozyme
Protein PPP2CA PDB 2iae.png
PDB rendering based on 2iae.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PPP2CA ; PP2Ac; PP2CA; PP2Calpha; RP-C
External IDs OMIM176915 MGI1321159 HomoloGene37660 ChEMBL: 4703 GeneCards: PPP2CA Gene
EC number 3.1.3.16
RNA expression pattern
PBB GE PPP2CA 208652 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5515 19052
Ensembl ENSG00000113575 ENSMUSG00000020349
UniProt P67775 P63330
RefSeq (mRNA) NM_002715 NM_019411
RefSeq (protein) NP_002706 NP_062284
Location (UCSC) Chr 5:
134.19 – 134.23 Mb
Chr 11:
52.1 – 52.13 Mb
PubMed search [1] [2]

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that (in humans) is encoded by the PPP2CA gene.[1]

Function[edit]

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.[2]

Interactions[edit]

PPP2CA has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590. 
  2. ^ "Entrez Gene: PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform". 
  3. ^ Deng X, Ito T, Carr B, Mumby M, May WS (Dec 1998). "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A". The Journal of Biological Chemistry 273 (51): 34157–63. PMID 9852076. 
  4. ^ Marmorstein LY, McLaughlin PJ, Stanton JB, Yan L, Crabb JW, Marmorstein AD (Aug 2002). "Bestrophin interacts physically and functionally with protein phosphatase 2A". The Journal of Biological Chemistry 277 (34): 30591–7. doi:10.1074/jbc.M204269200. PMID 12058047. 
  5. ^ Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". The Journal of Biological Chemistry 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189. 
  6. ^ a b c d e f g h i j k l m n o p Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. 
  7. ^ a b Cheng A, Kaldis P, Solomon MJ (Nov 2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms". The Journal of Biological Chemistry 275 (44): 34744–9. doi:10.1074/jbc.M006210200. PMID 10934208. 
  8. ^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. 
  9. ^ Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778. 
  10. ^ Chung H, Nairn AC, Murata K, Brautigan DL (Aug 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry 38 (32): 10371–6. doi:10.1021/bi990902g. PMID 10441131. 
  11. ^ a b Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081. 
  12. ^ Kamibayashi C, Lickteig RL, Estes R, Walter G, Mumby MC (Oct 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". The Journal of Biological Chemistry 267 (30): 21864–72. PMID 1328247. 
  13. ^ Yan Z, Fedorov SA, Mumby MC, Williams RS (Feb 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology 20 (3): 1021–9. PMC 85219. PMID 10629059. 
  14. ^ a b c d e McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. PMID 8703017. 
  15. ^ Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC 305594. PMID 10675325. 
  16. ^ Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. 

Further reading[edit]