This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.
^Hemmings BA, Adams-Pearson C, Maurer F, Müller P, Goris J, Merlevede W, Hofsteenge J, Stone SR (Apr 1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry. 29 (13): 3166–73. doi:10.1021/bi00465a002. PMID2159327.
^Baysal BE, Farr JE, Goss JR, Devlin B, Richard CW (Sep 1998). "Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23". Gene. 217 (1-2): 107–16. doi:10.1016/S0378-1119(98)00350-3. PMID9795170.
^Kamibayashi C, Lickteig RL, Estes R, Walter G, Mumby MC (Oct 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". The Journal of Biological Chemistry. 267 (30): 21864–72. PMID1328247.
^ abcdeMcCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID8703017.
Kamibayashi C, Lickteig RL, Estes R, Walter G, Mumby MC (Oct 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". The Journal of Biological Chemistry. 267 (30): 21864–72. PMID1328247.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID9013886.
Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". The Journal of Biological Chemistry. 272 (45): 28407–14. doi:10.1074/jbc.272.45.28407. PMID9353299.
Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID9400615.
Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J, Evans GA (Oct 1998). "Alterations of the PPP2R1B gene in human lung and colon cancer". Science. 282 (5387): 284–7. doi:10.1126/science.282.5387.284. PMID9765152.
Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (Jun 1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus". The Journal of Biological Chemistry. 274 (24): 17267–74. doi:10.1074/jbc.274.24.17267. PMID10358086.
Baysal BE, Willett-Brozick JE, Taschner PE, Dauwerse JG, Devilee P, Devlin B (Feb 2001). "A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region". European Journal of Human Genetics. 9 (2): 121–9. doi:10.1038/sj.ejhg.5200585. PMID11313745.
Ruediger R, Pham HT, Walter G (Apr 2001). "Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene". Oncogene. 20 (15): 1892–9. doi:10.1038/sj.onc.1204279. PMID11313937.
Yokoyama N, Reich NC, Miller WT (Jun 2001). "Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway". Journal of Interferon & Cytokine Research. 21 (6): 369–78. doi:10.1089/107999001750277844. PMID11440634.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID11531413.
Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID11929880.
Hemmer S, Wasenius VM, Haglund C, Zhu Y, Knuutila S, Franssila K, Joensuu H (Apr 2002). "Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas". Cancer Genetics and Cytogenetics. 134 (1): 13–7. doi:10.1016/S0165-4608(01)00597-0. PMID11996789.