PPP2R2C

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PPP2R2C
Identifiers
Aliases PPP2R2C, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma
External IDs MGI: 2442660 HomoloGene: 36386 GeneCards: PPP2R2C
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206994
NM_001206995
NM_001206996
NM_020416
NM_181876

NM_172994

RefSeq (protein)

NP_001193923
NP_001193924
NP_001193925
NP_065149
NP_870991

NP_766582.1
NP_766582

Location (UCSC) Chr 4: 6.32 – 6.56 Mb Chr 5: 36.87 – 36.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.[3][4][5]

Function[edit]

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (Oct 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research. 6 (5): 323–7. doi:10.1093/dnares/6.5.323. PMID 10574460. 
  4. ^ Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S (Jul 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics. 67 (1): 83–6. doi:10.1006/geno.2000.6219. PMID 10945473. 
  5. ^ a b "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform". 

Further reading[edit]