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Protein PPP2R4 PDB 2g62.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PTPA, PP2A, PR53, PPP2R4, protein phosphatase 2 regulatory subunit 4, protein phosphatase 2 phosphatase activator
External IDs MGI: 1346006 HomoloGene: 6149 GeneCards: PTPA
RNA expression pattern
PBB GE PPP2R4 206452 x at fs.png

PBB GE PPP2R4 216105 x at fs.png

PBB GE PPP2R4 208874 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 9: 129.11 – 129.15 Mb Chr 2: 30.42 – 30.45 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 2A regulatory subunit B' is an enzyme that in humans is encoded by the PPP2R4 gene.[3][4]

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]


PPP2R4 has been shown to interact with PPP2R3A,[5] CCNG1[6] and Janus kinase 2.[7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Van Hoof C, Aly MS, Garcia A, Cayla X, Cassiman JJ, Merlevede W, Goris J (Feb 1996). "Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A". Genomics. 28 (2): 261–72. doi:10.1006/geno.1995.1140. PMID 8530035. 
  4. ^ a b "Entrez Gene: PPP2R4 protein phosphatase 2A activator, regulatory subunit 4". 
  5. ^ Davis, Anthony J; Yan Zhen; Martinez Bobbie; Mumby Marc C (Jun 2008). "Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit". J. Biol. Chem. United States. 283 (23): 16104–14. doi:10.1074/jbc.M710313200. ISSN 0021-9258. PMC 2414307Freely accessible. PMID 18397887. 
  6. ^ Okamoto, K; Kamibayashi C; Serrano M; Prives C; Mumby M C; Beach D (Nov 1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. UNITED STATES. 16 (11): 6593–602. ISSN 0270-7306. PMC 231661Freely accessible. PMID 8887688. 
  7. ^ Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. UNITED STATES. 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385. 

Further reading[edit]