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Protein PPP2R5D PDB 2jak.png
Aliases PPP2R5D, B56D, MRD35, protein phosphatase 2 regulatory subunit B'delta, B56delta
External IDs MGI: 2388481 HomoloGene: 37661 GeneCards: PPP2R5D
RNA expression pattern
PBB GE PPP2R5D 211159 s at fs.png

PBB GE PPP2R5D 202513 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 42.98 – 43.01 Mb Chr 17: 46.68 – 46.71 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene.[3][4]


The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[4]


PPP2R5D has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McCright B, Virshup DM (Dec 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem. 270 (44): 26123–8. PMID 7592815. doi:10.1074/jbc.270.44.26123. 
  4. ^ a b "Entrez Gene: PPP2R5D protein phosphatase 2, regulatory subunit B', delta isoform". 
  5. ^ Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB (Nov 2003). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5): 1225–37. PMID 14636580. doi:10.1016/S1097-2765(03)00425-8. 
  6. ^ a b McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. PMID 8703017. doi:10.1074/jbc.271.36.22081. 
  7. ^ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. 8 (1): 157–71. PMC 2621004Freely accessible. PMID 18782753. doi:10.1074/mcp.M800266-MCP200. 
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 

Further reading[edit]