PPP3R1

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PPP3R1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PPP3R1, CALNB1, CNB, CNB1, protein phosphatase 3 regulatory subunit B, alpha
External IDs MGI: 107172 HomoloGene: 68099 GeneCards: PPP3R1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000945

NM_024459

RefSeq (protein)

NP_000936

NP_077779.2
NP_077779

Location (UCSC) Chr 2: 68.18 – 68.26 Mb Chr 11: 17.16 – 17.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.[3][4][5]

Clinical significance[edit]

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet. 72 (2-3): 236–41. doi:10.1159/000134198. PMID 8978785. 
  4. ^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868. 
  5. ^ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform". 
  6. ^ Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ, ed. "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLoS Genet. 6 (9): e1001101. doi:10.1371/journal.pgen.1001101. PMC 2940763Freely accessible. PMID 20862329. 

Further reading[edit]