PPP4C

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PPP4C
Identifiers
Aliases PPP4C, PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 catalytic subunit
External IDs MGI: 1891763 HomoloGene: 2038 GeneCards: PPP4C
RNA expression pattern
PBB GE PPP4C 208932 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303503
NM_001303504
NM_001303506
NM_001303507
NM_002720

NM_019674

RefSeq (protein)

NP_001290432
NP_001290433
NP_001290435
NP_001290436
NP_002711

NP_062648.1
NP_062648

Location (UCSC) Chr 16: 30.08 – 30.09 Mb Chr 7: 126.79 – 126.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.[3][4]

Interactions[edit]

PPP4C has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics. 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794. 
  4. ^ "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit". 
  5. ^ a b c d e f g h i j k l Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017Freely accessible. PMID 18715871. 
  6. ^ a b c d Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931. 
  7. ^ a b c d e f g h i j Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. 
  8. ^ Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778. 
  9. ^ Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938. 
  10. ^ Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters. 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786. 

Further reading[edit]