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Peroxiredoxin 4
Protein PRDX4 PDB 2pn8.png
PDB rendering based on 2pn8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRDX4 ; AOE37-2; AOE372; HEL-S-97n; PRX-4
External IDs OMIM300927 MGI1859815 HomoloGene4672 GeneCards: PRDX4 Gene
EC number
RNA expression pattern
PBB GE PRDX4 201923 at tn.png
More reference expression data
Species Human Mouse
Entrez 10549 53381
Ensembl ENSG00000123131 ENSMUSG00000025289
UniProt Q13162 O08807
RefSeq (mRNA) NM_006406 NM_016764
RefSeq (protein) NP_006397 NP_058044
Location (UCSC) Chr X:
23.66 – 23.69 Mb
Chr X:
155.32 – 155.34 Mb
PubMed search [1] [2]

Peroxiredoxin-4 is a protein that in humans is encoded by the PRDX4 gene.[1][2] It is a member of the peroxiredoxin family of antioxidant enzymes.


The protein encoded by this gene is an antioxidant enzyme of the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.[2]


PRDX4 has been shown to interact with Peroxiredoxin 1.[1]


  1. ^ a b Jin DY, Chae HZ, Rhee SG, Jeang KT (Jan 1998). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. PMID 9388242. 
  2. ^ a b "Entrez Gene: PRDX4 peroxiredoxin 4". 

Further reading[edit]