PRDX4

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PRDX4
Protein PRDX4 PDB 2pn8.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRDX4, AOE37-2, AOE372, HEL-S-97n, PRX-4, peroxiredoxin 4
External IDsOMIM: 300927 MGI: 1859815 HomoloGene: 4672 GeneCards: PRDX4
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for PRDX4
Genomic location for PRDX4
BandXp22.11Start23,664,262 bp[1]
End23,686,397 bp[1]
RNA expression pattern
PBB GE PRDX4 201923 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006406

NM_016764
NM_001313711

RefSeq (protein)

NP_006397

NP_001300640
NP_058044

Location (UCSC)Chr X: 23.66 – 23.69 MbChr X: 155.32 – 155.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxiredoxin-4 is a protein that in humans is encoded by the PRDX4 gene.[5][6] It is a member of the peroxiredoxin family of antioxidant enzymes.

Function[edit]

The protein encoded by this gene is an antioxidant enzyme of the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.[6]

Interactions[edit]

PRDX4 has been shown to interact with Peroxiredoxin 1.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123131 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025289 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Jin DY, Chae HZ, Rhee SG, Jeang KT (Jan 1998). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. PMID 9388242.
  6. ^ a b "Entrez Gene: PRDX4 peroxiredoxin 4".

Further reading[edit]