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Peroxiredoxin 5
Protein PRDX5 PDB 1h4o.png
PDB rendering based on 1h4o.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRDX5 ; ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20; PRDX6; PRXV; SBBI10; prx-V
External IDs OMIM606583 MGI1859821 HomoloGene8076 GeneCards: PRDX5 Gene
EC number
Species Human Mouse
Entrez 25824 54683
Ensembl ENSG00000126432 ENSMUSG00000024953
UniProt P30044 P99029
RefSeq (mRNA) NM_012094 NM_012021
RefSeq (protein) NP_036226 NP_036151
Location (UCSC) Chr 11:
64.32 – 64.32 Mb
Chr 19:
6.91 – 6.91 Mb
PubMed search [1] [2]

Peroxiredoxin-5, mitochondrial is a protein that in humans is encoded by the PRDX5 gene.[1][2][3]

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene.[3]


  1. ^ Yamashita H, Avraham S, Jiang S, London R, Van Veldhoven PP, Subramani S, Rogers RA, Avraham H (Nov 1999). "Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro". J Biol Chem 274 (42): 29897–904. doi:10.1074/jbc.274.42.29897. PMID 10514471. 
  2. ^ Knoops B, Clippe A, Bogard C, Arsalane K, Wattiez R, Hermans C, Duconseille E, Falmagne P, Bernard A (Nov 1999). "Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family". J Biol Chem 274 (43): 30451–8. doi:10.1074/jbc.274.43.30451. PMID 10521424. 
  3. ^ a b "Entrez Gene: PRDX5 peroxiredoxin 5". 

Further reading[edit]