PRIM2

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PRIM2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRIM2, PRIM2A, p58, primase (DNA) subunit 2
External IDs MGI: 97758 HomoloGene: 731 GeneCards: 5558
RNA expression pattern
PBB GE PRIM2A 205628 at tn.png

PBB GE PRIM2A 215708 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000947
NM_001282487
NM_001282488

NM_008922

RefSeq (protein)

NP_000938.2
NP_001269416.1
NP_001269417.1

NP_032948.1

Location (UCSC) Chr 6: 57.31 – 57.65 Mb Chr 1: 33.45 – 33.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.[1][2]

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[2]

References[edit]

  1. ^ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050. 
  2. ^ a b "Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa". 

Further reading[edit]