PRKAA2

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PRKAA2
Protein PRKAA2 PDB 2h6d.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2
External IDs MGI: 1336173 HomoloGene: 4551 GeneCards: PRKAA2
EC number 2.7.11.27
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PRKAA2
Genomic location for PRKAA2
Band 1p32.2 Start 56,645,322 bp[1]
End 56,715,335 bp[1]
RNA expression pattern
PBB GE PRKAA2 207709 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006252

NM_178143

RefSeq (protein)

NP_006243

NP_835279

Location (UCSC) Chr 1: 56.65 – 56.72 Mb Chr 1: 105.03 – 105.11 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.[5][6]

Function[edit]

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162409 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028518 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Aguan K, Scott J, See CG, Sarkar NH (Dec 1994). "Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals". Gene. 149 (2): 345–50. PMID 7959015. doi:10.1016/0378-1119(94)90174-0. 
  6. ^ a b "Entrez Gene: PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit". 

Further reading[edit]