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Protein PRKACB PDB 1apm.png
Aliases PRKACB, PKA C-beta, PKACB, protein kinase cAMP-activated catalytic subunit beta
External IDs MGI: 97594 HomoloGene: 121718 GeneCards: PRKACB
RNA expression pattern
PBB GE PRKACB 202741 at fs.png

PBB GE PRKACB 202742 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 1: 84.08 – 84.24 Mb Chr 3: 146.73 – 146.81 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.[3]

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of PKA. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.[3]


PRKACB has been shown to interact with Ryanodine receptor 2[4] and Low affinity nerve growth factor receptor.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: PRKACB protein kinase, cAMP-dependent, catalytic, beta". 
  4. ^ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. UNITED STATES. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164. 
  5. ^ Higuchi, Haruhisa; Yamashita Toshihide; Yoshikawa Hideki; Tohyama Masaya (April 2003). "PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts". EMBO J. England. 22 (8): 1790–800. doi:10.1093/emboj/cdg177. ISSN 0261-4189. PMC 154469Freely accessible. PMID 12682012. 

Further reading[edit]