PRKCG

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PRKCG
Protein PRKCG PDB 1tbn.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma
External IDs MGI: 97597 HomoloGene: 20602 GeneCards: PRKCG
Targeted by Drug
ingenol mebutate, balanol, enzastaurin, ruboxistaurin[1]
RNA expression pattern
PBB GE PRKCG 206270 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002739
NM_001316329

NM_001291434
NM_011102

RefSeq (protein)

NP_001303258
NP_002730

NP_035232.1
NP_001278363
NP_035232

Location (UCSC) Chr 19: 53.88 – 53.91 Mb Chr 7: 3.29 – 3.33 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.[4][5]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).[6]

Interactions[edit]

PRKCG has been shown to interact with GRIA4.[7]

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Protein kinase C gamma view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al. (Mar 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525. 
  5. ^ Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (Sep 1986). "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways". Science. 233 (4766): 859–66. doi:10.1126/science.3755548. PMID 3755548. 
  6. ^ "Entrez Gene: PRKCG protein kinase C, gamma". 
  7. ^ Correia, Susana Santos; Duarte Carlos Bandeira; Faro Carlos José; Pires Euclides Vieira; Carvalho Ana Luísa (Feb 2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. United States. 278 (8): 6307–13. doi:10.1074/jbc.M205587200. ISSN 0021-9258. PMID 12471040. 

External links[edit]

Further reading[edit]