PRKCH

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PRKCH
Protein PRKCH PDB 2fk9.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKCH, PKC-L, PKCL, PRKCL, nPKC-eta, protein kinase C eta
External IDs MGI: 97600 HomoloGene: 84384 GeneCards: PRKCH
Genetically Related Diseases
rheumatoid arthritis, morbid obesity[1]
Targeted by Drug
balanol[2]
RNA expression pattern
PBB GE PRKCH 206099 at tn.png

PBB GE PRKCH 218764 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006255

NM_008856
NM_001313977

RefSeq (protein)

NP_006246.2

NP_001300906.1
NP_032882.2

Location (UCSC) Chr 14: 61.19 – 61.55 Mb Chr 12: 73.58 – 73.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.[5][6][7]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.[7]

References[edit]

Further reading[edit]