PRKD3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PRKD3
Protein PRKD3 PDB 2d9z.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKD3, EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU, protein kinase D3
External IDs MGI: 1922542 HomoloGene: 2055 GeneCards: PRKD3
RNA expression pattern
PBB GE PRKD3 218236 s at fs.png

PBB GE PRKD3 211084 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005813

NM_001171004
NM_001171005
NM_029239

RefSeq (protein)

NP_005804

NP_083515.2
NP_001164475
NP_001164476
NP_083515

Location (UCSC) Chr 2: 37.25 – 37.32 Mb Chr 17: 78.95 – 79.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase D3 (PKD3) or PKC-nu is an enzyme that in humans is encoded by the PRKD3 gene.[3][4]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C gamma and the involvement of other PKC family members.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hayashi A, Seki N, Hattori A, Kozuma S, Saito T (Jun 1999). "PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu". Biochim Biophys Acta. 1450 (1): 99–106. doi:10.1016/S0167-4889(99)00040-3. PMID 10231560. 
  4. ^ a b "Entrez Gene: PRKD3 protein kinase D3". 

Further reading[edit]