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Protein PRKD3 PDB 2d9z.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesPRKD3, EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU, protein kinase D3
External IDsOMIM: 607077 MGI: 1922542 HomoloGene: 2055 GeneCards: PRKD3
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PRKD3
Genomic location for PRKD3
Band2p22.2Start37,250,502 bp[1]
End37,324,808 bp[1]
RNA expression pattern
PBB GE PRKD3 218236 s at fs.png

PBB GE PRKD3 211084 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 37.25 – 37.32 MbChr 17: 78.95 – 79.02 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase D3 (PKD3) or PKC-nu is an enzyme that in humans is encoded by the PRKD3 gene.[5][6]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C gamma and the involvement of other PKC family members.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115825 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024070 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hayashi A, Seki N, Hattori A, Kozuma S, Saito T (Jun 1999). "PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu". Biochim Biophys Acta. 1450 (1): 99–106. doi:10.1016/S0167-4889(99)00040-3. PMID 10231560.
  6. ^ a b "Entrez Gene: PRKD3 protein kinase D3".

Further reading[edit]