PRKRA

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
PRKRA
Protein PRKRA PDB 2dix.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKRA, DYT16, PACT, RAX, HSD14, protein activator of interferon induced protein kinase EIF2AK2
External IDs MGI: 1344375 HomoloGene: 2738 GeneCards: PRKRA
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PRKRA
Genomic location for PRKRA
Band 2q31.2 Start 178,431,414 bp[1]
End 178,451,512 bp[1]
RNA expression pattern
PBB GE PRKRA 209139 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001139517
NM_001139518
NM_001316362
NM_003690

NM_011871

RefSeq (protein)

NP_001132989
NP_001132990
NP_001303291
NP_003681

NP_036001

Location (UCSC) Chr 2: 178.43 – 178.45 Mb Chr 2: 76.63 – 76.65 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.[5][6][7] PACT heterodimerizes with and activates protein kinase R.[6][8] PRKRA mutations have been linked to a rare form of dystonia parkinsonism.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180228 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002731 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator". 
  6. ^ a b Patel RC, Sen GC (August 1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR". EMBO J. 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771Freely accessible. PMID 9687506. 
  7. ^ Ito T, Yang M, May WS (May 1999). "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling". J. Biol. Chem. 274 (22): 15427–32. doi:10.1074/jbc.274.22.15427. PMID 10336432. 
  8. ^ Huang X, Hutchins B, Patel RC (August 2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748Freely accessible. PMID 11985496. 
  9. ^ Camargos S, Scholz S, Simón-Sánchez J, Paisán-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, Singleton AB (March 2008). "DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA". Lancet Neurology. 7 (3): 207–215. doi:10.1016/S1474-4422(08)70022-X. PMID 18243799. 

Further reading[edit]