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Pre-mRNA processing factor 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRPF4 ; HPRP4; HPRP4P; PRP4; Prp4p; RP70; SNRNP60
External IDs OMIM607795 MGI1917302 HomoloGene3446 ChEMBL: 1163119 GeneCards: PRPF4 Gene
RNA expression pattern
PBB GE PRPF4 209162 s at tn.png
PBB GE PRPF4 209161 at tn.png
More reference expression data
Species Human Mouse
Entrez 9128 70052
Ensembl ENSG00000136875 ENSMUSG00000066148
UniProt O43172 Q9DAW6
RefSeq (mRNA) NM_001244926 NM_027297
RefSeq (protein) NP_001231855 NP_081573
Location (UCSC) Chr 9:
113.28 – 113.29 Mb
Chr 4:
62.41 – 62.43 Mb
PubMed search [1] [2]

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene.[1][2][3]

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][3]


Further reading[edit]