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Available structures
PDB Ortholog search: PDBe RCSB
Aliases PRPF4B, PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDs MGI: 109584 HomoloGene: 134085 GeneCards: PRPF4B
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 4.02 – 4.06 Mb Chr 13: 34.88 – 34.91 Mb
PubMed search [1] [2]
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Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[3][4][5]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).[5]


PRPF4B has been shown to interact with Pinin.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581. doi:10.1093/dnares/5.1.31. 
  4. ^ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. PMID 11418604. doi:10.1074/jbc.M103790200. 
  5. ^ a b "Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)". 
  6. ^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. United States. 22 (14): 5141–56. ISSN 0270-7306. PMC 139773Freely accessible. PMID 12077342. doi:10.1128/MCB.22.14.5141-5156.2002. 

Further reading[edit]