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Available structures
PDBOrtholog search: PDBe RCSB
AliasesPRPF4B, PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDsOMIM: 602338 MGI: 109584 HomoloGene: 134085 GeneCards: PRPF4B
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PRPF4B
Genomic location for PRPF4B
Band6p25.2Start4,021,267 bp[1]
End4,064,983 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 4.02 – 4.06 MbChr 13: 34.88 – 34.91 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[5][6][7]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).[7]


PRPF4B has been shown to interact with Pinin.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112739 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021413 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ^ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.
  7. ^ a b "Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)".
  8. ^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. United States. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. hdl:11858/00-001M-0000-0029-BC76-A. ISSN 0270-7306. PMC 139773. PMID 12077342.

Further reading[edit]