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Aliases PRRX2, PMX2, PRX2, paired related homeobox 2
External IDs MGI: 98218 HomoloGene: 7524 GeneCards: PRRX2
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PRRX2
Genomic location for PRRX2
Band 9q34.11 Start 129,665,641 bp[1]
End 129,722,674 bp[1]
RNA expression pattern
PBB GE PRRX2 219729 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 129.67 – 129.72 Mb Chr 9: 30.83 – 30.88 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.[5][6]


The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167157 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039476 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (Mar 2001). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm Genome. 11 (11): 1000–5. doi:10.1007/s003350010193. PMID 11063257. 
  6. ^ a b "Entrez Gene: PRRX2 paired related homeobox 2". 

Further reading[edit]