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Paired related homeobox 2
Symbols PRRX2 ; PMX2; PRX2
External IDs OMIM604675 MGI98218 HomoloGene7524 GeneCards: PRRX2 Gene
RNA expression pattern
PBB GE PRRX2 219729 at tn.png
More reference expression data
Species Human Mouse
Entrez 51450 20204
Ensembl ENSG00000167157 ENSMUSG00000039476
UniProt Q99811 Q06348
RefSeq (mRNA) NM_016307 NM_009116
RefSeq (protein) NP_057391 NP_033142
Location (UCSC) Chr 9:
129.67 – 129.72 Mb
Chr 2:
30.83 – 30.88 Mb
PubMed search [1] [2]

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.[1][2]


The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.[2]


  1. ^ Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (Mar 2001). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm Genome 11 (11): 1000–5. doi:10.1007/s003350010193. PMID 11063257. 
  2. ^ a b "Entrez Gene: PRRX2 paired related homeobox 2". 

Further reading[edit]