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Protein PRSS8 PDB 3DFJ.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesPRSS8, CAP1, PROSTASIN, protease, serine 8, serine protease 8
External IDsMGI: 1923810 HomoloGene: 20613 GeneCards: PRSS8
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for PRSS8
Genomic location for PRSS8
Band16p11.2Start31,131,433 bp[1]
End31,135,762 bp[1]
RNA expression pattern
PBB GE PRSS8 202525 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 16: 31.13 – 31.14 MbChr 7: 127.93 – 127.93 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Prostasin is a protein that in humans is encoded by the PRSS8 gene.[5][6][7]

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

The protein is implicated in epithelial sodium channel regulation[8] and may help regulate a variety of tissue functions that involve a sodium channel.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000052344 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030800 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Yu JX, Chao L, Ward DC, Chao J (Mar 1996). "Structure and chromosomal localization of the human prostasin (PRSS8) gene". Genomics. 32 (3): 334–40. doi:10.1006/geno.1996.0127. PMID 8838796. 
  6. ^ Yu JX, Chao L, Chao J (Jun 1995). "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA". The Journal of Biological Chemistry. 270 (22): 13483–9. doi:10.1074/jbc.270.22.13483. PMID 7768952. 
  7. ^ "Entrez Gene: PRSS8 protease, serine, 8". 
  8. ^ Koda A, Wakida N, Toriyama K, Yamamoto K, Iijima H, Tomita K, Kitamura K (Apr 2009). "Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity". Hypertension Research. 32 (4): 276–81. doi:10.1038/hr.2009.6. PMID 19262497. 
  9. ^ Zhu H, Guo D, Li K, Yan W, Tan Y, Wang X, Treiber FA, Chao J, Snieder H, Dong Y (Sep 2008). "Prostasin: a possible candidate gene for human hypertension". American Journal of Hypertension. 21 (9): 1028–33. doi:10.1038/ajh.2008.224. PMC 3812941Freely accessible. PMID 18583984. 

Further reading[edit]