CYTH3

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CYTH3
Protein PSCD3 PDB 1bc9.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CYTH3, ARNO3, GRP1, PSCD3, cytohesin 3
External IDs MGI: 1335107 HomoloGene: 3116 GeneCards: CYTH3
RNA expression pattern
PBB GE PSCD3 206523 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004227

NM_001163548
NM_011182

RefSeq (protein)

NP_004218

NP_035312.3
NP_001157020
NP_035312

Location (UCSC) Chr 7: 6.16 – 6.27 Mb Chr 5: 143.62 – 143.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.[3][4]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP (Apr 1997). "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains". Science. 275 (5308): 1927–30. doi:10.1126/science.275.5308.1927. PMID 9072969. 
  4. ^ a b "Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3". 

Further reading[edit]