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AliasesCYTH4, CYT4, DJ63G5.1, PSCD4, cytohesin 4, cytohesin-4
External IDsOMIM: 606514 MGI: 2441702 HomoloGene: 22750 GeneCards: CYTH4
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CYTH4
Genomic location for CYTH4
Band22q13.1Start37,282,027 bp[1]
End37,315,341 bp[1]
RNA expression pattern
PBB GE PSCD4 219183 s at fs.png

PBB GE PSCD4 211521 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 22: 37.28 – 37.32 MbChr 15: 78.6 – 78.62 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.[5][6]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100055 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018008 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  6. ^ a b "Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4".

Further reading[edit]