PSME3

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PSME3
Identifiers
Aliases PSME3, HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA, proteasome activator subunit 3
External IDs MGI: 1096366 HomoloGene: 2111 GeneCards: PSME3
RNA expression pattern
PBB GE PSME3 209852 x at fs.png

PBB GE PSME3 200987 x at fs.png

PBB GE PSME3 200988 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267045
NM_005789
NM_176863
NM_001330229

NM_011192

RefSeq (protein)

NP_001253974
NP_001317158
NP_005780
NP_789839

NP_035322.1
NP_035322

Location (UCSC) Chr 17: 42.82 – 42.84 Mb Chr 11: 101.32 – 101.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Proteasome activator complex subunit 3 is a protein that in humans is encoded by the PSME3 gene.[3][4]

Function[edit]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.[4]

Interactions[edit]

PSME3 has been shown to interact with P53[5] and Mdm2.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Albertsen HM, Smith SA, Mazoyer S, Fujimoto E, Stevens J, Williams B, Rodriguez P, Cropp CS, Slijepcevic P, Carlson M (Dec 1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID 7951316. 
  4. ^ a b "Entrez Gene: PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)". 
  5. ^ a b Zhang Z, Zhang R (Mar 2008). "Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation". EMBO J. 27 (6): 852–64. doi:10.1038/emboj.2008.25. PMC 2265109Freely accessible. PMID 18309296. 

Further reading[edit]

External links[edit]