PTF1A

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PTF1A
Identifiers
Aliases PTF1A, PACA, PAGEN2, PTF1-p48, bHLHa29, pancreas specific transcription factor, 1a
External IDs MGI: 1328312 HomoloGene: 10304 GeneCards: PTF1A
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178161

NM_018809

RefSeq (protein)

NP_835455

NP_061279.2
NP_061279

Location (UCSC) Chr 10: 23.19 – 23.19 Mb Chr 2: 19.45 – 19.45 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pancreas transcription factor 1 subunit alpha is a protein that in humans is encoded by the PTF1A gene.[3][4]

Function[edit]

This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Knöfler M, Krapp A, Hagenbüchle O, Wellauer PK (Sep 1996). "Constitutive expression of the gene for the cell-specific p48 DNA-binding subunit of pancreas transcription factor 1 in cultured cells is under control of binding sites for transcription factors Sp1 and alphaCbf". The Journal of Biological Chemistry. 271 (36): 21993–2002. doi:10.1074/jbc.271.36.21993. PMID 8703005. 
  4. ^ a b "Entrez Gene: PTF1A pancreas specific transcription factor, 1a". 

Further reading[edit]