MPGES-1

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PTGES
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTGES, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1, prostaglandin E synthase
External IDsOMIM: 605172 MGI: 1927593 HomoloGene: 3587 GeneCards: PTGES
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PTGES
Genomic location for PTGES
Band9q34.11Start129,738,331 bp[1]
End129,753,042 bp[1]
RNA expression pattern
PBB GE PTGES 210367 s at fs.png

PBB GE PTGES 207388 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004878
NM_198797

NM_022415

RefSeq (protein)

NP_004869

NP_071860

Location (UCSC)Chr 9: 129.74 – 129.75 MbChr 2: 30.89 – 30.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microsomal prostaglandin E synthase-1 (mPGES-1)[5][6] or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.[7][8][9]

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.[9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148344 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050737 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jakobsson PJ, Thorén S, Morgenstern R, et al. (1989). "Identification of human prostaglandin E synthase: a microsomal glutathione-dependent, inducible enzyme, constituting a potential novel drug target". Proc Natl Acad Sci USA. 96: 7220–7225. doi:10.1073/pnas.96.13.7220. PMC 22058. PMID 10377395.
  6. ^ Hui-Hua Chang; Emmanuelle J Meuillet (2011). "Identification and development of mPGES-1 inhibitors: where we are at?". Future Med Chem. 3 (15): 1909–1934. doi:10.4155/fmc.11.136. PMC 3232027. PMID 22023034.
  7. ^ Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847.
  8. ^ Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B (May 1999). "Common structural features of MAPEG -- a widespread superfamily of membrane-associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Sci. 8 (3): 689–92. doi:10.1110/ps.8.3.689. PMC 2144274. PMID 10091672.
  9. ^ a b "Entrez Gene: PTGES prostaglandin E synthase".

Further reading[edit]