PTGES

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PTGES
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTGES, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1, prostaglandin E synthase
External IDs MGI: 1927593 HomoloGene: 3587 GeneCards: PTGES
RNA expression pattern
PBB GE PTGES 210367 s at fs.png

PBB GE PTGES 207388 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004878
NM_198797

NM_022415

RefSeq (protein)

NP_004869

NP_071860.1
NP_071860

Location (UCSC) Chr 9: 129.74 – 129.75 Mb Chr 2: 30.89 – 30.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.[3][4][5]

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847. 
  4. ^ Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B (May 1999). "Common structural features of MAPEG -- a widespread superfamily of membrane-associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Sci. 8 (3): 689–92. doi:10.1110/ps.8.3.689. PMC 2144274Freely accessible. PMID 10091672. 
  5. ^ a b "Entrez Gene: PTGES prostaglandin E synthase". 

Further reading[edit]