Parathyroid hormone 2 receptor

From Wikipedia, the free encyclopedia
  (Redirected from PTHR2)
Jump to: navigation, search
PTH2R
Identifiers
Aliases PTH2R, PTHR2, parathyroid hormone 2 receptor
External IDs MGI: 2180917 HomoloGene: 3701 GeneCards: PTH2R
RNA expression pattern
PBB GE PTHR2 206772 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001309516
NM_005048

NM_139270

RefSeq (protein)

NP_001296445
NP_005039

NP_644676.1
NP_644676

Location (UCSC) Chr 2: 208.36 – 208.85 Mb Chr 1: 65.28 – 65.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene[3]

Function[edit]

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.[3]

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding [4]


See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: PTH2R parathyroid hormone 2 receptor". 
  4. ^ Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.". Biochemical Pharmacology. doi:10.1016/j.bcp.2016.12.013. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.