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Protein PTP4A1 PDB 1rxd.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesPTP4A1, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1, protein tyrosine phosphatase type IVA, member 1
External IDsMGI: 1277096 HomoloGene: 2587 GeneCards: PTP4A1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PTP4A1
Genomic location for PTP4A1
Band6q12Start63,521,746 bp[1]
End63,583,377 bp[1]
RNA expression pattern
PBB GE PTP4A1 200730 s at fs.png

PBB GE PTP4A1 200733 s at fs.png

PBB GE PTP4A1 200731 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 63.52 – 63.58 MbChr 1: 30.94 – 30.95 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.[5][6]

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.[6]


PTP4A1 has been shown to interact with ATF7.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112245 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026064 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Peng Y, Genin A, Spinner NB, Diamond RH, Taub R (Aug 1998). "The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer". J Biol Chem. 273 (27): 17286–95. doi:10.1074/jbc.273.27.17286. PMID 9642300.
  6. ^ a b "Entrez Gene: PTP4A1 protein tyrosine phosphatase type IVA, member 1".
  7. ^ Peters, C S; Liang X; Li S; Kannan S; Peng Y; Taub R; Diamond R H (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. United States. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. ISSN 0021-9258. PMID 11278933.

Further reading[edit]