PTP4A2

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PTP4A2
Identifiers
Aliases PTP4A2, HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b, protein tyrosine phosphatase type IVA, member 2
External IDs MGI: 1277117 HomoloGene: 20744 GeneCards: PTP4A2
RNA expression pattern
PBB GE PTP4A2 208617 s at fs.png

PBB GE PTP4A2 208616 s at fs.png

PBB GE PTP4A2 208615 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195100
NM_001195101
NM_003479
NM_080391
NM_080392

NM_001164745
NM_008974

RefSeq (protein)

NP_001182029
NP_001182030
NP_536316

NP_001158217.1
NP_033000.1
NP_001158217
NP_033000

Location (UCSC) Chr 1: 31.91 – 31.94 Mb Chr 4: 129.81 – 129.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.[3][4][5]

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants that encode two distinct isoforms have been described.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zhao Z, Lee CC, Monckton DG, Yazdani A, Coolbaugh MI, Li X, Bailey J, Shen Y, Caskey CT (Sep 1996). "Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase". Genomics. 35 (1): 172–81. doi:10.1006/geno.1996.0336. PMID 8661118. 
  4. ^ Zeng Q, Hong W, Tan YH (Apr 1998). "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1". Biochem Biophys Res Commun. 244 (2): 421–7. doi:10.1006/bbrc.1998.8291. PMID 9514946. 
  5. ^ a b "Entrez Gene: PTP4A2 protein tyrosine phosphatase type IVA, member 2". 

Further reading[edit]