PTP4A3

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PTP4A3
Protein PTP4A3 PDB 1r6h.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTP4A3, PRL-3, PRL-R, PRL3, protein tyrosine phosphatase type IVA, member 3
External IDs MGI: 1277098 HomoloGene: 22500 GeneCards: PTP4A3
RNA expression pattern
PBB GE PTP4A3 209695 at fs.png

PBB GE PTP4A3 214223 at fs.png

PBB GE PTP4A3 206574 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007079
NM_032611

NM_001166388
NM_001166389
NM_001166390
NM_008975

RefSeq (protein)

NP_009010
NP_116000

Location (UCSC) Chr 8: 141.39 – 141.43 Mb Chr 15: 73.72 – 73.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.[3]

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.[3]

References[edit]

Further reading[edit]