The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.
Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (Jun 1994). "The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID7545953.
Ogata M, Takada T, Mori Y, Oh-hora M, Uchida Y, Kosugi A, Miyake K, Hamaoka T (Apr 1999). "Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells". The Journal of Biological Chemistry. 274 (18): 12905–9. doi:10.1074/jbc.274.18.12905. PMID10212280.
Ogata M, Takada T, Mori Y, Uchida Y, Miki T, Okuyama A, Kosugi A, Sawada M, Oh-hora M, Hamaoka T (Jul 1999). "Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion". The Journal of Biological Chemistry. 274 (29): 20717–24. doi:10.1074/jbc.274.29.20717. PMID10400706.
Aoyama K, Matsuda T, Aoki N (Dec 1999). "Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36". Biochemical and Biophysical Research Communications. 266 (2): 523–31. doi:10.1006/bbrc.1999.1845. PMID10600535.
Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Sep 2000). "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation". Journal of Cell Science. 113 ( Pt 17) (17): 3117–23. PMID10934049.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID15324660.
Barr AJ, Debreczeni JE, Eswaran J, Knapp S (Jun 2006). "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution". Proteins. 63 (4): 1132–6. doi:10.1002/prot.20958. PMID16534812.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.