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Protein tyrosine phosphatase, non-receptor type 14
Protein PTPN14 PDB 2bzl.png
PDB rendering based on 2bzl.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTPN14 ; PEZ; PTP36
External IDs OMIM603155 MGI102467 HomoloGene3941 GeneCards: PTPN14 Gene
EC number
RNA expression pattern
PBB GE PTPN14 205503 at tn.png
More reference expression data
Species Human Mouse
Entrez 5784 19250
Ensembl ENSG00000152104 ENSMUSG00000026604
UniProt Q15678 Q62130
RefSeq (mRNA) NM_005401 NM_001033287
RefSeq (protein) NP_005392 NP_033002
Location (UCSC) Chr 1:
214.35 – 214.55 Mb
Chr 1:
189.73 – 189.88 Mb
PubMed search [1] [2]

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.[2]


PTPN14 has been shown to interact with Beta-catenin.[3]


  1. ^ Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (May 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochem Biophys Res Commun 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990. 
  2. ^ a b "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14". 
  3. ^ Wadham, Carol; Gamble Jennifer R, Vadas Mathew A, Khew-Goodall Yeesim (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Mol. Biol. Cell (United States) 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. ISSN 1059-1524. PMC 194899. PMID 12808048. 

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