PTPN18

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PTPN18
Protein PTPN18 PDB 2oc3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPN18, BDP1, PTP-HSCF, protein tyrosine phosphatase, non-receptor type 18
External IDs MGI: 108410 HomoloGene: 74971 GeneCards: PTPN18
RNA expression pattern
PBB GE PTPN18 213521 at fs.png

PBB GE PTPN18 203555 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142370
NM_014369

NM_011206

RefSeq (protein)

NP_001135842
NP_055184

NP_035336.2
NP_035336

Location (UCSC) Chr 2: 130.36 – 130.38 Mb Chr 1: 34.46 – 34.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.[3][4]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.[4]

Interactions[edit]

PTPN18 has been shown to interact with PSTPIP1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kim YW, Wang H, Sures I, Lammers R, Martell KJ, Ullrich A (January 1997). "Characterization of the PEST family protein tyrosine phosphatase BDP1". Oncogene. 13 (10): 2275–9. PMID 8950995. 
  4. ^ a b "Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)". 
  5. ^ Spencer, S; Dowbenko D; Cheng J; Li W; Brush J; Utzig S; Simanis V; Lasky L A (August 1997). "PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase". J. Cell Biol. UNITED STATES. 138 (4): 845–60. doi:10.1083/jcb.138.4.845. ISSN 0021-9525. PMC 2138048Freely accessible. PMID 9265651. 

Further reading[edit]