PTPN2

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PTPN2
Protein PTPN2 PDB 1l8k.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPN2, PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP, protein tyrosine phosphatase, non-receptor type 2
External IDs MGI: 97806 HomoloGene: 7497 GeneCards: 5771
Genetically Related Diseases
Disease Name References
Rheumatoid Arthritis
esophagus squamous cell carcinoma
coeliac disease
Crohn's disease
diabetes mellitus type 1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001207013
NM_001308287
NM_002828
NM_080422
NM_080423

NM_001127177
NM_008977

RefSeq (protein)

NP_001193942.1
NP_002819.2
NP_536347.1
NP_536348.1

NP_001120649.1
NP_033003.1

Location (UCSC) Chr 18: 12.79 – 12.93 Mb Chr 18: 67.67 – 67.72 Mb
PubMed search [6] [7]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.[2]

References[edit]

  1. ^ Brown-Shimer S, Johnson KA, Lawrence JB, Johnson C, Bruskin A, Green NR, Hill DE (Aug 1990). "Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B". Proc Natl Acad Sci U S A 87 (13): 5148–52. doi:10.1073/pnas.87.13.5148. PMC 54279. PMID 2164224. 
  2. ^ a b "Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2". 

Further reading[edit]