PTPN2

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PTPN2
Protein PTPN2 PDB 1l8k.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN2, PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP, protein tyrosine phosphatase, non-receptor type 2
External IDsMGI: 97806 HomoloGene: 7497 GeneCards: PTPN2
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for PTPN2
Genomic location for PTPN2
Band18p11.21Start12,785,478 bp[1]
End12,929,643 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001207013
NM_001308287
NM_002828
NM_080422
NM_080423

NM_001127177
NM_008977

RefSeq (protein)

NP_001193942
NP_001295216
NP_002819
NP_536347
NP_536348

NP_001120649
NP_033003

Location (UCSC)Chr 18: 12.79 – 12.93 MbChr 18: 67.67 – 67.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.[5][6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175354 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024539 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Brown-Shimer S, Johnson KA, Lawrence JB, Johnson C, Bruskin A, Green NR, Hill DE (Aug 1990). "Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B". Proc Natl Acad Sci U S A. 87 (13): 5148–52. doi:10.1073/pnas.87.13.5148. PMC 54279. PMID 2164224.
  6. ^ a b "Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2".

Further reading[edit]