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AliasesPTPN21, PTPD1, PTPRL10, protein tyrosine phosphatase, non-receptor type 21, protein tyrosine phosphatase non-receptor type 21
External IDsOMIM: 603271 MGI: 1344406 HomoloGene: 5110 GeneCards: PTPN21
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PTPN21
Genomic location for PTPN21
Band14q31.3Start88,465,778 bp[1]
End88,555,007 bp[1]
RNA expression pattern
PBB GE PTPN21 40524 at fs.png

PBB GE PTPN21 1320 at fs.png

PBB GE PTPN21 205438 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 14: 88.47 – 88.56 MbChr 12: 98.68 – 98.74 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.[5][6]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.[6]


PTPN21 has been shown to interact with BMX[7] and KIF1C.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070778 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021009 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Møller NP, Møller KB, Lammers R, Kharitonenkov A, Sures I, Ullrich A (Sep 1994). "Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain". Proc Natl Acad Sci USA. 91 (16): 7477–81. doi:10.1073/pnas.91.16.7477. PMC 44424. PMID 7519780.
  6. ^ a b "Entrez Gene: PTPN21 protein tyrosine phosphatase, non-receptor type 21".
  7. ^ Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (Dec 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
  8. ^ Dorner C, Ciossek T, Müller S, Møller PH, Ullrich A, Lammers R (Aug 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J. Biol. Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.

Further reading[edit]