PTPN4

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PTPN4
Protein PTPN4 PDB 2cs5.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN4, MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4
External IDsMGI: 1099792 HomoloGene: 2120 GeneCards: PTPN4
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PTPN4
Genomic location for PTPN4
Band2q14.2Start119,759,631 bp[1]
End119,983,818 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002830

NM_019933

RefSeq (protein)

NP_002821

NP_064317

Location (UCSC)Chr 2: 119.76 – 119.98 MbChr 1: 119.65 – 119.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.[6]

Interactions[edit]

PTPN4 has been shown to interact with GRID2.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088179 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026384 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. doi:10.1073/pnas.88.13.5867. PMC 51979Freely accessible. PMID 1648233. 
  6. ^ a b "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)". 
  7. ^ Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123. 

Further reading[edit]