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Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Protein PTPN4 PDB 2cs5.png
PDB rendering based on 2cs5.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM176878 MGI1099792 HomoloGene2120 ChEMBL: 3165 GeneCards: PTPN4 Gene
EC number
Species Human Mouse
Entrez 5775 19258
Ensembl ENSG00000088179 ENSMUSG00000026384
UniProt P29074 Q9WU22
RefSeq (mRNA) NM_002830 NM_019933
RefSeq (protein) NP_002821 NP_064317
Location (UCSC) Chr 2:
119.76 – 119.98 Mb
Chr 1:
119.65 – 119.84 Mb
PubMed search [1] [2]

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.[1][2]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.[2]


PTPN4 has been shown to interact with GRID2.[3]


  1. ^ Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A 88 (13): 5867–71. doi:10.1073/pnas.88.13.5867. PMC 51979. PMID 1648233. 
  2. ^ a b "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)". 
  3. ^ Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123. 

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