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Available structures
PDB Ortholog search: PDBe RCSB
Aliases PTPRE, HPTPE, PTPE, R-PTP-EPSILON, protein tyrosine phosphatase, receptor type E
External IDs MGI: 97813 HomoloGene: 31387 GeneCards: PTPRE
RNA expression pattern
PBB GE PTPRE 221840 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 10: 127.91 – 128.09 Mb Chr 7: 135.54 – 135.69 Mb
PubMed search [1] [2]
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Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene.[3][4]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.[4]


PTPRE has been shown to interact with KCNB1.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ van den Maagdenberg AM, van den Hurk HH, Weghuis D, Wieringa B, Geurts van Kessel A, Hendriks WJ (April 1996). "Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization". Genomics. 30 (1): 128–9. doi:10.1006/geno.1995.0026. PMID 8595895. 
  4. ^ a b "Entrez Gene: PTPRE protein tyrosine phosphatase, receptor type, E". 
  5. ^ Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A (August 2000). "Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon". EMBO J. 19 (15): 4036–45. doi:10.1093/emboj/19.15.4036. PMC 306594Freely accessible. PMID 10921884. 

Further reading[edit]