PTPRG

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PTPRG
Protein PTPRG PDB 2h4v.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPRG, HPTPG, PTPG, R-PTP-GAMMA, RPTPG, protein tyrosine phosphatase, receptor type G
External IDs MGI: 97814 HomoloGene: 2129 GeneCards: PTPRG
Genetically Related Diseases
Fuchs' endothelial dystrophy[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002841

NM_008981
NM_001347593

RefSeq (protein)

NP_002832

NP_033007.2
NP_001334522
NP_033007

Location (UCSC) Chr 3: 61.56 – 62.3 Mb Chr 14: 11.55 – 12.24 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.[4][5]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.[5]

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