PTPRO

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PTPRO
Protein PTPRO PDB 2g59.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O, protein tyrosine phosphatase receptor type O
External IDsOMIM: 600579 MGI: 1097152 HomoloGene: 21564 GeneCards: PTPRO
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for PTPRO
Genomic location for PTPRO
Band12p12.3|12p13-p12Start15,322,508 bp[1]
End15,598,331 bp[1]
RNA expression pattern
PBB GE PTPRO 208121 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164401
NM_001164402
NM_001164403
NM_011216

RefSeq (protein)

NP_001157873
NP_001157874
NP_001157875
NP_035346

Location (UCSC)Chr 12: 15.32 – 15.6 MbChr 6: 137.25 – 137.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.[5][6][7]

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151490 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030223 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. PMID 7519601.
  6. ^ Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.
  7. ^ a b "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".

Further reading[edit]