PTPRO

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PTPRO
Protein PTPRO PDB 2g59.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O
External IDs MGI: 1097152 HomoloGene: 21564 GeneCards: PTPRO
RNA expression pattern
PBB GE PTPRO 208121 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164401
NM_001164402
NM_001164403
NM_011216

RefSeq (protein)

NP_035346.3
NP_001157873
NP_001157874
NP_001157875
NP_035346

Location (UCSC) Chr 12: 15.32 – 15.6 Mb Chr 6: 137.25 – 137.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.[3][4][5]

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. PMID 7519601. 
  4. ^ Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166. 
  5. ^ a b "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O". 

Further reading[edit]