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Protein tyrosine phosphatase, receptor type, O
Protein PTPRO PDB 2g59.png
PDB rendering based on 2g59.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600579 MGI1097152 HomoloGene21564 IUPHAR: 1863 GeneCards: PTPRO Gene
EC number
RNA expression pattern
PBB GE PTPRO 208121 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5800 19277
Ensembl ENSG00000151490 ENSMUSG00000030223
UniProt Q16827 E9Q612
RefSeq (mRNA) NM_002848 NM_001164401
RefSeq (protein) NP_002839 NP_001157873
Location (UCSC) Chr 12:
15.48 – 15.75 Mb
Chr 6:
137.25 – 137.46 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.[1][2][3]

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.[3]


  1. ^ Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem 269 (31): 19953–62. PMID 7519601. 
  2. ^ Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166. 
  3. ^ a b "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O". 

Further reading[edit]