PTPRR

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PTPRR
Protein PTPRR PDB 1jln.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPRR, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R
External IDs MGI: 109559 HomoloGene: 2135 GeneCards: PTPRR
RNA expression pattern
PBB GE PTPRR 210675 s at fs.png

PBB GE PTPRR 206084 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001207015
NM_001207016
NM_002849
NM_130846

NM_001161837
NM_001161838
NM_001161839
NM_001161840
NM_011217

RefSeq (protein)

NP_001193944
NP_001193945
NP_002840
NP_570897

Location (UCSC) Chr 12: 70.64 – 70.92 Mb Chr 10: 116.02 – 116.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.[3][4][5]

Function[edit]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.[5]

Interactions[edit]

PTPRR has been shown to interact with MAPK7.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H (Nov 1995). "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase". Gene. 162 (2): 279–84. doi:10.1016/0378-1119(95)00306-Q. PMID 7557444. 
  4. ^ van den Maagdenberg AM, Schepens JT, Schepens MT, Merkx GF, Darroudi F, Wieringa B, Geurts van Kessel A, Hendriks WJ (Jul 1999). "Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization". Cytogenet Cell Genet. 84 (3-4): 243–4. doi:10.1159/000015268. PMID 10393441. 
  5. ^ a b "Entrez Gene: PTPRR protein tyrosine phosphatase, receptor type, R". 
  6. ^ Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (Aug 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33): 29503–9. doi:10.1074/jbc.M202149200. PMID 12042304. 

Further reading[edit]