PTPRZ1

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PTPRZ1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPRZ1, HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, protein tyrosine phosphatase, receptor type Z1, protein tyrosine phosphatase receptor type Z1
External IDsOMIM: 176891 MGI: 97816 HomoloGene: 2136 GeneCards: PTPRZ1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for PTPRZ1
Genomic location for PTPRZ1
Band7q31.32Start121,873,089 bp[1]
End122,062,036 bp[1]
RNA expression pattern
PBB GE PTPRZ1 204469 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206838
NM_001206839
NM_002851
NM_001369395
NM_001369396

NM_001081306
NM_011219
NM_178180
NM_001311064
NM_001361349

RefSeq (protein)

NP_001193767
NP_001193768
NP_002842

NP_001074775
NP_001297993
NP_001348278
NP_035349

Location (UCSC)Chr 7: 121.87 – 122.06 MbChr 6: 22.88 – 23.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.[5][6][7]

Function[edit]

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[7]

Clinical significance[edit]

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106278 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068748 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T, Yakura H (Jun 1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenet Cell Genet. 70 (1–2): 52–4. doi:10.1159/000133990. PMID 7736789.
  6. ^ Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM, Huang JT, Cannizzaro LA, Park SH, Druck T (Jun 1993). "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". J Biol Chem. 268 (14): 10573–81. PMID 8387522.
  7. ^ a b c "Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1".

Further reading[edit]