PTPRZ1

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PTPRZ1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPRZ1, HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, protein tyrosine phosphatase, receptor type Z1
External IDs MGI: 97816 HomoloGene: 2136 GeneCards: PTPRZ1
RNA expression pattern
PBB GE PTPRZ1 204469 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206838
NM_001206839
NM_002851

NM_001081306
NM_011219
NM_178180
NM_001311064

RefSeq (protein)

NP_001193767
NP_001193768
NP_002842

NP_001074775.1
NP_001074775
NP_001297993

Location (UCSC) Chr 7: 121.87 – 122.06 Mb Chr 6: 22.88 – 23.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.[3][4][5]

Function[edit]

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[5]

Clinical significance[edit]

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T, Yakura H (Jun 1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenet Cell Genet. 70 (1–2): 52–4. doi:10.1159/000133990. PMID 7736789. 
  4. ^ Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM, Huang JT, Cannizzaro LA, Park SH, Druck T (Jun 1993). "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". J Biol Chem. 268 (14): 10573–81. PMID 8387522. 
  5. ^ a b c "Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1". 

Further reading[edit]