PUM1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PUM1
Protein PUM1 PDB 1ib2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PUM1, HSPUM, PUMH, PUMH1, PUML1, pumilio RNA binding family member 1
External IDs MGI: 1931749 HomoloGene: 22830 GeneCards: 9698
RNA expression pattern
PBB GE PUM1 201164 s at tn.png

PBB GE PUM1 201165 s at tn.png

PBB GE PUM1 201166 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014676
NM_001020658

NM_001159603
NM_001159604
NM_001159605
NM_001159606
NM_030722

RefSeq (protein)

NP_001018494.1
NP_055491.1

NP_001153075.1
NP_001153076.1
NP_001153077.1
NP_001153078.1
NP_109647.2

Location (UCSC) Chr 1: 30.93 – 31.07 Mb Chr 4: 130.66 – 130.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.[1]

Function[edit]

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

References[edit]

Further reading[edit]