Poliovirus receptor-related 2

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Poliovirus receptor-related 2 (herpesvirus entry mediator B)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PVRL2 ; CD112; HVEB; PRR2; PVRR2
External IDs OMIM600798 HomoloGene86092 GeneCards: PVRL2 Gene
RNA expression pattern
PBB GE PVRL2 203149 at tn.png
More reference expression data
Species Human Mouse
Entrez 5819 19294
Ensembl ENSG00000130202 ENSMUSG00000062300
UniProt Q92692 P32507
RefSeq (mRNA) NM_001042724 NM_001159724
RefSeq (protein) NP_001036189 NP_001153196
Location (UCSC) Chr 19:
44.85 – 44.89 Mb
Chr 7:
19.72 – 19.75 Mb
PubMed search [1] [2]

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.[1]


This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.