Poliovirus receptor-related 2

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NECTIN2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDs MGI: 97822 HomoloGene: 86092 GeneCards: NECTIN2
Genetically Related Diseases
Alzheimer's disease, age related macular degeneration[1]
RNA expression pattern
PBB GE PVRL2 203149 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042724
NM_002856

NM_001159724
NM_008990

RefSeq (protein)

NP_001036189
NP_002847

NP_001153196.1
NP_033016.3
NP_001153196
NP_033016

Location (UCSC) Chr 19: 44.85 – 44.89 Mb Chr 7: 19.72 – 19.75 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.[4]

Function[edit]

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[4]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.