PYCR1

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PYCR1
Protein PYCR1 PDB 2ger.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR, pyrroline-5-carboxylate reductase 1
External IDsOMIM: 179035 MGI: 2384795 HomoloGene: 56002 GeneCards: PYCR1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for PYCR1
Genomic location for PYCR1
Band17q25.3Start81,932,384 bp[1]
End81,942,412 bp[1]
RNA expression pattern
PBB GE PYCR1 202148 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144795
NM_001348222

RefSeq (protein)

NP_659044
NP_001335151

Location (UCSC)Chr 17: 81.93 – 81.94 MbChr 11: 120.64 – 120.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene.[5][6]

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183010 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025140 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dougherty KM, Brandriss MC, Valle D (Feb 1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae". J Biol Chem. 267 (2): 871–5. PMID 1730675.
  6. ^ a b "Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1".

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)