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Pyrroline-5-carboxylate reductase 1
Protein PYCR1 PDB 2ger.png
PDB rendering based on 2ger.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PYCR1 ; ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222; PRO3; PYCR
External IDs OMIM179035 MGI2384795 HomoloGene56002 GeneCards: PYCR1 Gene
EC number
RNA expression pattern
PBB GE PYCR1 202148 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5831 209027
Ensembl ENSG00000183010 ENSMUSG00000025140
UniProt P32322 Q922W5
RefSeq (mRNA) NM_001282279 NM_144795
RefSeq (protein) NP_001269208 NP_659044
Location (UCSC) Chr 17:
81.93 – 81.94 Mb
Chr 11:
120.64 – 120.64 Mb
PubMed search [1] [2]

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene.[1][2]

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.[2]


  1. ^ Dougherty KM, Brandriss MC, Valle D (Feb 1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae". J Biol Chem 267 (2): 871–5. PMID 1730675. 
  2. ^ a b "Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1". 

Further reading[edit]