The single peaked at #1 on the BillboardBubbling Under R&B/Hip-Hop Singles in the December 2, 2006 issue of Billboard magazine. It was also a top ten hit in Ireland and peaked at number 21 in the UK. On MTV Australia, "Pac's Life" peaked at the number 1 spot on the Hip Hop Countdown, beating new releases from Jay-Z, Eminem and 50 Cent, and Nas.
The original version of the song samples Prince's "Pop Life" and is a minute and 34 seconds in duration, with some speculating it might have been cut off when it was initially leaked. It first features Tupac's verse and Tupac singing the hook.
The video made its world premiere on the BET music network in the United States on November 22, 2006. The video was featured on BET's Access Granted, where viewers saw the process of filming the video for "Pac's Life". Both T.I. and Ashanti were featured in the long-awaited video, which was filmed at the Tupac Amaru Shakur Center for the Arts, in Atlanta, Georgia. The video premiered on MTV on November 28, 2006.