Palace of the Holy Office

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An aerial view of the Paul VI Audience Hall with the Palace of the Holy Office behind (with orange facade)

The Palace of the Holy Office (Italian: Palazzo del Sant'Uffizio) is a building in Rome which is an extraterritorial property of Vatican City. It houses the curial Congregation for the Doctrine of the Faith.

Built in the 16th century, the palace is situated south of St Peter's Basilica near the Petriano Entrance to Vatican City.

The building lies outside the confines of Vatican City at the south-eastern corner of the city-state. It is one of the properties of the Holy See in Italy regulated by the 1929 Lateran Treaty signed with the Kingdom of Italy. As such, it has extraterritorial status.

It is where Joseph Cardinal Ratzinger (now Pope Emeritus Benedict XVI) worked as Prefect of the Congregation.

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Coordinates: 41°54′3.7″N 12°27′21.9″E / 41.901028°N 12.456083°E / 41.901028; 12.456083