According to Houbraken, his father was a Flemish sculptor who carved semi-precious stone such as jasper, porphyry, and agate into vases and other decorative art. His father had traveled to England in service of King James of Scotland, but after young Palamedes was born the family returned to Delft where the boys grew up. Houbraken mentions that his talent was so good that Palamedes became a master without having had a master, and only practised by copying the works of Esaias van de Velde, which he did so well that he became very well known. His motto was "to begin from the beginning", but his beginning was only just started when he died at 31 on 26 March 1638.
Palamedes primarily painted battle scenes that were mentioned in Cornelis de Bie's Het Gulden Cabinet. His brother became a respected portrait painter. According to the RKD, he was in Antwerp in 1631, but returned to Delft in 1632.
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- Vermeer and The Delft School, a full text exhibition catalog from The Metropolitan Museum of Art, which contains material on Palamedes Palamedesz