It was built by the Besta family around 1433, commissioned by Azzo I and Azzo II Besta, perhaps over a pre-existing medieval edifice. Later it was owned by the Guicciardi, Quadrio and Parravicini families. It is now owned by Lombardy.
The interior has a rectangular court with a double loggia, frescoed walls (c. 1540-1630) and an octagonal well. In the first floor, all the rooms are frescoed with mythological themes, most of them from the Aeneid, the Orlando Furioso and the Bible. One, by Giuseppe Prina, portrays the Queen of Sheba received by King Solomon.
In the lower ground is housed the "Antiquarium Tellinum" Museum, housing prehistorical slabs.
- Galletti, Giorgio; Germano Mulazzani (1983). Il Palazzo Besta di Teglio. Una dimora rinascimentale in Valtellina. Sondrio: Banca Piccolo Credito Valtellinese.
- Palazzo Besta, Polo museale della Lombardia (in Italian) (in English)
- Palazzo Besta, Lombardia Beni Culturali (in Italian)
- Palazzo Besta Virtual visit of the palace