Palmatine

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palmatine
Palmatine.png
Names
IUPAC name
2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
Other names
Berbericinine
Identifiers
3D model (Jmol)
ChemSpider
UNII
Properties
C21H22NO4+
Molar mass 352.4083 g/mol
Density 1.23 g/cm3
Boiling point 482.9 °C (901.2 °F; 756.0 K) at 760 mmHg
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Palmatine is a protoberberine alkaloid found in several plants including Phellodendron amurense, Rhizoma coptidis/Coptis Chinensis and Corydalis yanhusuo.[1]

It is the major component of the protoberberine extract from Enantia chlorantha.[2]

It has been studied for its potential use in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.[3] This compound also has weak in vitro activity against flavivirus.[4]

See also[edit]

References[edit]

  1. ^ Wang YM, Zhao LB, Lin SL, Dong SS, An DK (1989). "[Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by HPLC]". Yao Xue Xue Bao = Acta Pharmaceutica Sinica (in Chinese). 24 (4): 275–9. PMID 2816389. 
  2. ^ Virtanen P., Njimi T.,Ekotto Mengata D.:Clinical trials of hepatitis cure with protoberberine alkaloids of Enantia Chlorantha (abstract) Eur.J.Clin.Pharmacol.36: A123, 1989b
  3. ^ Bhadra K, Kumar GS (January 2010). "Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: Binding aspects and implications for drug design". Medicinal Research Reviews. 31: 821–862. doi:10.1002/med.20202. PMID 20077560. 
  4. ^ Jia F., Zou G., Fan J., Yuan Z."Identification of palmatine as an inhibitor of West Nile virus" Archives of Virology 2010 155:8 (1325-1329)