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Palo santo may refer to:
- Lignum vitae, heartwood of tree species of the genus Guaiacum, native to subtropical and tropical regions of the Americas
- Bulnesia sarmientoi, a tree species native to the Gran Chaco area in South America
- Bursera graveolens, a tree species native to South America, used for incense, aromatic oil, and indigenous medicine
- Palo Santo (Shearwater album), a 2006 album by indie rock band Shearwater, or the title track
- Palo Santo (Years & Years album), a 2018 album by British band Years & Years, or the title track
| disambiguation page lists articles associated with the title Palo santo.
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