Pam Brady first met Parker, Stone and Jason McHugh while working under Brian Graden at the Fox Broadcasting Company. Brady suggested that the two make a weekly version of their student film Cannibal! The Musical. The three came up with the idea for Time Warped. While Time Warped was not produced, Parker and Stone decided to make South Park for Comedy Central and brought Brady on as a writer.
Brady is known as the live-action fiancée of Mr. Adler in the episode "Tweek vs. Craig". Although Brady left the show in the fourth season to write Hollywood films and co-create the short-lived series The Loop, she would later co-write Team America: World Police and occasionally produce or consult on episodes of the series. Brady wrote and directed the horror-inspired animated TV series Neighbors from Hell, which premiered in June 2010 on TBS.
Brady began collaborating with Arrested Development creator Mitch Hurwitz to create a television show starring Maria Bamford. The series, Lady Dynamite, was released on Netflix on May 20, 2016.
- The John Larroquette Show (1993)
- South Park (1997–1999)
- Just Shoot Me! (1999–2000)
- Mr. Wong (2000) (also co-creator)
- Go Fish (2001) (also developer)
- The Loop (2006–2007) (also co-creator)
- Neighbors from Hell (2010) (also creator)
- Lady Dynamite (2016–2017) (also co-creator)
- South Park: Bigger, Longer & Uncut (1999) - with Trey Parker and Matt Stone
- Team America: World Police (2004) - with Parker and Stone
- Hot Rod (2007)
- Hamlet 2 (2008) - with Andrew Fleming
- The Bubble (2022) - with Judd Apatow