Pancreatic acinar metaplasia

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Pancreatic acinar metaplasia
Pancreatic acinar metaplasia - high mag.jpg
Micrograph of a gastro-esophageal junction with pancreatic acinar metaplasia. The esophageal mucosa (stratified squamous epithelium) is seen on the right. The gastric mucosa (simple columnar epithelium) is seen on the left. The metaplastic epithelial is at the junction (center of image) and has an intensely eosinophilic (bright pink) cytoplasm. H&E stain.
Classification and external resources

Pancreatic acinar metaplasia (PAM) is a common incidental histopathologic finding present in approximately 20-25% of patients undergoing an esophagogastroduodenoscopy.[1][2]


Studies are mixed on whether it is associated with pathology and symptoms.[2] There is some epidemiological evidence to suggest is associated with gastroesophageal reflux and Helicobacter gastritis.[1]

There is no evidence to suggest it is pre-neoplastic, like Barrett's esophagus.


A slight increased incidence with age suggests, it is an acquired lesion,[1] as may be seen in a true metaplasia.


The histopathologic features of pancreatic acinar metaplasia are: (1) the presence of cell clusters that resembles a many-lobed "berry" (an acinus), with (2) cells that are histomorphologically identical to the glands of the exocrine pancreas.

See also[edit]


  1. ^ a b c Johansson J, Håkansson HO, Mellblom L, et al. (March 2010). "Pancreatic acinar metaplasia in the distal oesophagus and the gastric cardia: prevalence, predictors and relation to GORD". J. Gastroenterol. 45 (3): 291–9. doi:10.1007/s00535-009-0161-4. PMID 20012917. 
  2. ^ a b Wang HH, Zeroogian JM, Spechler SJ, Goyal RK, Antonioli DA (December 1996). "Prevalence and significance of pancreatic acinar metaplasia at the gastroesophageal junction". Am. J. Surg. Pathol. 20 (12): 1507–10. doi:10.1097/00000478-199612000-00010. PMID 8944044.